![]() They also explored potential BCR public clonotype elicitation by the vaccine.įour seronegative and five seropositive health care workers (HCWs) were enrolled in the study. In the present study, researchers extended their previous analysis by comparatively assessing BCR repertoires of seropositive and seronegative persons to assess the impact of prior COVID-19 history on B lymphocyte responses to the Pfizer SARS-CoV-2 mRNA vaccine. However, the impact of prior SARS-CoV-2 exposure on the immune responses of BCR repertoire to COVID-19 vaccinations is unclear. The authors of the present study previously reported that anti-SARS-CoV-2 S titers in response to SARS-CoV-2 vaccinations are higher among seropositive persons (with prior COVID-19 history) than seronegative persons (without prior COVID-19 history). Common (or public) SARS-CoV-2 clonotypes have been reported among different persons, indicative of evolutionary convergence across the repertoires. Higher somatic hypermutations (SHM) rates have been reported in response to natural SARS-CoV-2 infections but not vaccinations, indicative of different B cell receptor (BCR) responses to and natural infections. Image Credit: Cinefootage Visuals/Shutterstock BackgroundĬharacterizing B lymphocyte responses to coronavirus disease 2019 (COVID-19) vaccines by prior SARS-CoV-2 exposure would deepen understanding of probable B cell memory use by vaccines. Study: Effects of Prior Infection with SARS-CoV-2 on B Cell Receptor Repertoire Response during Vaccination. In a recent study published in Vaccines, researchers evaluated immune responses by B lymphocytes to Pfizer’s severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA (messenger ribonucleic acid) vaccine. By Pooja Toshniwal Paharia Reviewed by Danielle Ellis, B.Sc.
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